Abstract: 【Abstract】ObjectiveTo study the damage effect of lobaplatin (LBP) and cisplatin (DDP) on human umbilical vein endothelia cell line (HUVECs)，human liver cell line (QSG7701) and human renal tubular epithelial cells (HK-2 cells)，and to explore the possible mechanismMethodsThe proliferation responses of HUVECs，QSG-7701 and HK2 cells treated with LBP or DDP in the concentration of 3.125ug/ml were observed by MTT assayIn addition，the concentrations of malondialdehyde (MDA) and superoxide dismutase (SOD) were determined in HK2 cellsResultsWith the same concentration and action time，the inhibition effect of DDP on HK2 cells was significantly higher than that of LBP (P＜0.05)，while the inhibition effect of LBP on HUVECs was significantly higher that that of DDP (P＜0.05)The inhibition rate of these two drugs on QSG7701 was not significantly different (P＞0.05)The level of MDA in LBPtreated group or DDPtreated group was significantly higher than that in control group (P＜0.05)，the level of SOD in both platinum groups was significantly lower than that in control group (P＜0.05)，while both the levels of MAD and SOD were not significantly different between LBPtreated group and DDPtreated group (both P＞0.05)Conclusion LBP and DDP displayed inhibitive effect on human hepatocytes and renal tubular epithelial cellsLBP might have stronger antiangiogenesis effect on HUVECs comparing to DDPOxidative damage may be a common mechanism of renal toxicity caused by LBP and DDP

Key words: 【Key words】 Platinum, HUVECs, QSG-7701, HK-2 , cells